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Coq10 for fertility

CoQ10 for Fertility: Does It Really Works?

Ladies and gents, if you’re here to delve into the world of fertility, we’re thrilled to embark on this journey with you. Whether you’ve explored the landscape of fertility supplements like Revosit and Profertil or are simply curious about optimising your reproductive health, join us as we navigate the intricate realm of fertility and unravel the science, myths, and tips that may contribute to the miracle of life.

Those familiar with Revosit and Profertil might have noticed the presence of this star ingredient — CoQ10.

What even is that? How does it boost my fertility?

CoQ10 is short for Coenzyme Q10, and is a fat-soluble compound that our bodies produce. It is mostly found in our mitochondria — an organelle in our cells that carries out chemical processes (aerobic respiration) to generate energy in the form of ATP molecules.

CoQ10 proponents claim it enhances energy, supports mitochondrial function, combats free radicals and inflammation, enhances heart health, lowers blood sugar and blood pressure, alleviates migraines, aids fertility, and mitigates side effects of statins and chemotherapy.

Unfortunately, as we grow old, we begin to produce less CoQ10. Thankfully, we can still obtain it from external sources like supplementation or whole foods.

For females:

CoQ10 acts like an “protector”, scavenging free radicals that may potentially attack your eggs. It neutralises reactive oxygen species (ROS) that can damage the mitochondrial DNA and mess up the mitochondrial membrane’s integrity, causing the organelle to be dysfunctional and unable to produce enough energy. Without CoQ10’s protection, your eggs may not have enough energy to carry out essential processes for proper maturation — inhibiting fertility.

CoQ10 can also act like a “summoner”, calling upon other soldiers to help. It can regenerate other antioxidants, such as vitamin E. After vitamin E neutralises a free radical, it becomes oxidised. CoQ10 helps to regenerate the oxidised form of vitamin E back to its active, antioxidant form, allowing it to continue protecting cells from oxidative damage.

There is also evidence that CoQ10 increases levels of superoxide dismutase — an enzyme that helps neutralise a free radical called superoxide — in the body.

Additionally, CoQ10 can prevent ovarian inflammation. In females with PCOS, there are elevated levels of pro-inflammatory cytokines — interleukin-6, interleukin-8 and tumour necrosis factor alpha — which can result in chronic inflammation.

As the body’s immune system continuously attacks its own ovarian tissue, follicular dysfunction and hormonal imbalances occur, leading to infertility. However, in several studies, CoQ10 showed signs of downregulating these pro-inflammatory cytokines, granting hope for those with PCOS.

For males:

CoQ10 can boost sperm cell motility, once again through its ROS-scavenging property. The sperm cell’s tail, especially, contains a large amount of polyunsaturated fatty acids, which ROS love to target. But fret not, CoQ10 can neutralise these ROS and prevent them from damaging the sperm cell membrane.

Furthermore, CoQ10 plays an important role in mitochondrial function. It acts as a mobile electron carrier, aiding the process of oxidative phosphorylation in the electron transport chain of the mitochondria. This helps to prevent electrons from leaking, forming ROS.

Simultaneously, it helps the mitochondria to generate energy in the form of ATP molecules more efficiently! This means sperm cells may be able to get an “energy boost” from CoQ10, enabling it to swim faster to the egg.

That’s great! Now, how much CoQ10 should I take?

Most people taking CoQ10 for regular health benefits stick to the 100-500mg range. However, some people have even gone up to 1800 mg per day.

A medical study on male fertility showed that 400 mg/day was much more effective than 200 mg/day. Some clinical trials have even experimented with 3000 mg, claiming that it had benefitted cognitive function in patients with neurodegenerative diseases such as Parkinson’s.

According to a 2009 study, a human’s maximum tolerability of CoQ10 plateaus at 2400 mg. It states that the maximum plasma CoQ10 concentration reached a maximum at 2400 mg, suggesting the saturation point in absorption. Efficiency of absorption decreased with increasing dose.

Our recommendation: Anything below 500 mg is just for regular health benefits. If you want that real enhancement, you can try up to 1800 mg, gradually increasing as you go (because there may be gastro-intestinal implications such as nausea and diarrhoea, although the side-effects of the drug are few).

There may also be additional benefits to stacking up on CoQ10. Good news for the gym junkies — CoQ10 is known for increasing power output for intense workouts. And more importantly, it possesses anti-inflammatory properties which help with muscle recuperation after all that hard work and lactic acid buildup.

How do I maximise my CoQ10 absorption? Which form should I take?

Soft gels tend to be better absorbed than capsules or other preparations. Higher doses may be recommended for specific conditions. CoQ10 is fat soluble, so it should be taken with a meal containing fat so your body can absorb it. Also, taking CoQ10 at night may help with the body’s ability to use it. (Speaking of nighttime, does this remind you of our melatonin article? Read more to find out about melatonin’s effect on fertility. You may even consider taking CoQ10 together with melatonin.)

One significant benefit of delivering nutrients through soft gels lies in their ability to enhance the bioavailability of active ingredients compared to tablets, capsules, or powders.

According to the Food and Drug Administration (FDA), bioavailability is described as “the rate and extent to which the therapeutic moiety is absorbed and becomes available to the site of action.” Basically, bioavailability = amount of a substance absorbed by the body.

Patients also usually report reduced stomach pain when digesting soft gels than when taking tablets or rigid two-piece capsules. This is great because the side-effects of CoQ10 are usually related to gastro-intestinal discomforts. Taking soft-gels may hence alleviate these side-effects.

But I already take Revosit/Profertil. Isn’t that enough for my reproductive health?

Short answer: No! If you take a look at the nutrition labels, Revosit only contains 100 mg of CoQ10. Profertil is even worse, containing only a teensy 15 mg for males and 30 mg for females. To be very honest, it seems quite useless to even include CoQ10 in the formula.

Hence, although these products have claimed to benefit fertility, we propose that it wouldn’t hurt to stack up on more CoQ10.

Should I take CoQ10 for IVF?

Short answer: Yes.

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