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nac supplement for fertility dosage male female fertility

NAC supplement for fertility is considered among the best for aiding conception. NAC is a special substance that can do a lot for our health. It’s made from an amino acid called L-cysteine and it’s really good at fighting off bad stuff in our bodies. One of its superpowers is making more of something called glutathione, which helps protect our cells. But NAC isn’t just about antioxidants – it can also help our bodies clean out toxins, boost our immune system, and even make a difference for people trying to have a baby. As we learn more about NAC and its potential, we’re discovering new ways it might help us stay healthy.

nac supplement for fertility dosage male female fertility
What is NAC?

NAC, short for N-Acetyl Cysteine, is a derivative of the amino acid L-cysteine. It has an additional acetyl group attached to the cysteine molecule, making it more stable and bioavailable than L-cysteine itself.

NAC plays a crucial role in the production of glutathione, a powerful antioxidant that protects cells from damage caused by free radicals. Free radicals are unstable molecules that can damage DNA, proteins, and other cellular components, contributing to various health issues.

While NAC itself has some antioxidant activity, its primary benefit lies in boosting glutathione levels, significantly enhancing the body’s overall antioxidant defense system.

Beyond its antioxidant role, NAC may also participate in:

  • Detoxification pathways by supporting the liver and kidneys
  • Immune system function by modulating specific immune cells
  • Inflammatory processes by reducing pro-inflammatory molecules

The body can synthesize NAC from L-cysteine, which is found in protein-rich foods like poultry, fish, eggs, and dairy. NAC is also available as a dietary supplement in various forms, including capsules, tablets, and powder.

Benefits of NAC

NAC offers a range of potential benefits, though further research is needed to confirm and fully understand their extent in all cases. Here are some of the potential benefits:

Respiratory Health:

  • Thinning mucus: NAC may help thin mucus in the airways, making it easier to cough up and potentially easing symptoms of respiratory conditions like chronic obstructive pulmonary disease (COPD).
  • Reducing inflammation: NAC’s anti-inflammatory properties may be helpful in managing inflammatory airway conditions like asthma or reducing recurrence of women’s health conditions like endometriosis. 
nac supplement for fertility dosage male female fertility
nac supplement for fertility dosage male female fertility

Immune Function:

  • Boosting glutathione: By increasing glutathione levels, NAC may indirectly support the immune system’s ability to fight off infections and illnesses.

Other Potential Benefits:

  • Brain health: Studies suggest NAC may improve cognitive function and memory, potentially benefiting conditions like Alzheimer’s and Parkinson’s disease.
  • Mental health: NAC may help reduce symptoms of anxiety and depression, although more research is needed.
  • Fertility: Some studies suggest NAC supplement for fertility is good to take both for men and women fertility.
  • Detoxification: NAC may support the liver and kidneys in detoxification processes.
7 NAC Supplements to Help Fertility
Editor's Choice

1. Xymogen NAC

Xymogen NAC is a dietary supplement that contains N-Acetyl-L-Cysteine (NAC), which is a form of the amino acid L-cysteine. NAC is a precursor to glutathione, which is an important antioxidant in the body. Xymogen NAC is marketed as a supplement that can support detoxification, cardiovascular health, and immune function.

This product is made with N-Acetyl-L-Cysteine, capsule (HPMC), stearic acid, magnesium stearate, and silicon dioxide with the claim to supports glutathione synthesis, detoxification of environmental toxins and pollutant, antioxidant activity in all body cells, and healthy respiratory function.

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Xymogen NAC

  • Pros: Strong antioxidant action, which is good for fertility while supporting healthy liver function and detoxification. Is purity and contaminant-tested.
  • Cons: More expensive than other NAC supplement for fertility
  • Price: S$0.91/600 mg capsule
Buy Xymogen NAC at Amazon SG
Affordable NAC to Help Fertility

2. LiverDoctor NAC N-Acetyl-L-Cysteine 600mg

LiverDoctor NAC N-Acetyl-L-Cysteine 600mg is a high-dose NAC supplement for fertility designed to support liver health and detoxification. It comes in capsule form and is made with non-GMO ingredients.

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LiverDoctor NAC N-Acetyl L-Cysteine 600mg

  • Pros: Affordable. Made with non-GMO ingredients.
  • Cons: Not as well-known as other NAC brands.
  • Price: S$0.69/ 600mg capsule
Buy LiverDoctor NAC 600mg at Amazon SG

3. Nootropics Depot NAC 500mg

Swanson CoQ10 120mg provides an affordable solution for fertility support with each serving containing 120mg of ubiquinone CoQ10. Available in softgel form, it offers convenience and ease of consumption. While some users may experience occasional digestive upset  and despite its lower dosage compared to other options, its affordability and third-party testing make it a trustworthy choice for individuals seeking reliable fertility support.

CoQ10 for fertility supplements gummies

Nootropics Depot NAC 500mg

  • Pros: Affordable. Effective
  • Cons: May not be as effective as higher-dose NAC supplements. Not as well-known as other NAC brands
  • Price: S$0.58/500mg capsule
Buy Nootropics Depot NAC 500mg at Amazon SG
NAC with Other Supplements

4. Kappa Nutrition NAC 600mg plus Quercetin 1000mg

Kappa Nutrition NAC 600mg is a dietary supplement that contains N-acetyl-L-cysteine (NAC) together with Quercetin and a host of other complementary vitamins and minerals. 

Quercetin’s antioxidant properties play a pivotal role in protecting reproductive tissues from oxidative damage, thereby preserving sperm and egg health. Its ability to neutralize free radicals helps maintain the integrity of DNA in both male and female reproductive cells, crucial for successful conception.

The benefits of quercetin at 1000mg are amplified when paired with 600mg of NAC. This partnership between quercetin and NAC not only strengthens antioxidant defenses but also supports hormonal balance, crucial for reproductive health.

Furthermore, quercetin exhibits anti-inflammatory properties, which can alleviate inflammation in the reproductive organs, potentially improving fertility outcomes. By working in tandem, quercetin and NAC create a comprehensive approach to fertility support, addressing both oxidative stress and inflammation, common barriers to conception.

Studies suggest that this combination may offer enhanced fertility benefits compared to individual supplementation, making it a promising option for couples seeking to optimize their reproductive health. Quercetin is also a useful supplement for those suffering from allergic conditions like eczema and allergic rhinitis.

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Kappa Nutrition NAC 600mg plus Quercetin 1000mg

  • Pros: Affordable NAC supplement for fertility. Also contains Quercetin, which can be helpful not just for fertility but also for people with allergic tendencies. Made with non-GMO.
  • Cons: Not as well-known a brand. Not a pure product, and is optimized for those who also need and respond well to Quercetin.
  • Price: S$0.73/600mg capsule
Buy Kappa Nutrition NAC 600mg plus Quercetin 1000mg at Amazon SG

5. Now Foods NAC Plus Molybdenum and Selenium

Now Foods is a well-known and affordable supplement brand. This particular NOW product contains not just NAC 500mg, but also molybdenum 50mcg and selenium 25mcg.

Molybdenum is an essential trace mineral that plays a crucial role in various physiological processes within the human body. In combination with NAC, the key benefit of molybdenum is its antioxidant effect.

Molybdenum-containing enzymes, such as aldehyde oxidase and xanthine oxidase, help neutralize harmful free radicals and reactive oxygen species (ROS) generated during metabolic processes. By scavenging these oxidative molecules, molybdenum contributes to cellular protection against oxidative stress and reduces the risk of oxidative damage to DNA, proteins, and lipids.

In the context of women’s reproductive health, molybdenum’s antioxidant properties may help protect ovarian tissue from oxidative damage and support hormonal balance, both of which are essential for ovulation and fertility.

In the context of male fertility, optimal sperm production and function rely on proper sulfur metabolism and antioxidant protection. Molybdenum’s role in these processes may help support sperm quality and motility, thereby improving fertility outcomes.

Additionally, because molybdenum facilitates the body’s detoxification processes, it may help reduce the burden of environmental toxins that could otherwise impair reproductive health.

One of the primary ways selenium benefits the body is through its antioxidant activity. As an essential component of glutathione peroxidases, selenium helps catalyze the conversion of hydrogen peroxide and lipid hydroperoxides into harmless compounds, thereby reducing oxidative stress and preventing cellular damage.

In terms of fertility, selenium is believed to offer several benefits for both men and women. As an antioxidant, selenium helps protect reproductive cells, including sperm and eggs, from oxidative damage, thereby preserving their integrity and viability. Studies have shown that selenium supplementation may improve sperm quality, motility, and DNA integrity in men, leading to enhanced fertility outcomes.

Furthermore, selenium’s role in thyroid hormone metabolism is crucial for female reproductive health, as thyroid hormones play a key role in regulating menstrual cycles, ovulation, and fertility. Selenium deficiency can disrupt thyroid function and hormone balance, potentially leading to menstrual irregularities and infertility in women. By supporting thyroid health, selenium may help promote optimal reproductive function and improve fertility in women.

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Now Foods NAC Plus Molybdenum and Selenium

  • Pros: Affordable. It also includes selenium 25mcg and molybdenum 50mcg.
  • Cons: If you are looking for a pure product, this is not NAC only. If you are consuming 3 capsulesfor 1500mg of NAC, it means you have to also consume 75mcg of selenium and 150mcg of molybdenum. Supplementation with molybdenum is typically unnecessary for individuals consuming a balanced diet rich in fruits, vegetables, whole grains, legumes, nuts, and seeds, as these foods are good sources of this essential mineral.
  • Price: S$0.58/500mg capsule
Buy Now Foods NAC Plus Molybdenum and Selenium at Amazon SG
Best Vegan NAC for Fertility

6. BlueBonnet NAC 500 mg Vitamin Capsules

BlueBonnet NAC 500 mg Vitamin Capsules are for the vegans among us! Each capsule contains 500 mg of NAC, and they are made with non-GMO ingredients and are vegetarian and vegan-friendly.

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BlueBonnet NAC 500mg Vitamin Capsules

  • Pros: Made with non-GMO ingredients. Is a vegan product.
  • Cons: Not exactly cheap.
Buy BlueBonnet NAC 500mg Vitamin Capsules at Amazon SG
Powder-form NAC for Fertility

7. MYOXCIENCE NAC + Glycine Supreme

MYOXCIENCE NAC + Glycine Supreme is a blend of NAC and glycine, also known as Gly-NAC. Gly-NAC has the potential to support cognitive function and is a top longevity supplement! It comes in powder form and is mixed with water or juice to drink.

One of the key benefits of Gly-NAC is its powerful antioxidant capacity. By replenishing intracellular glutathione levels, Gly-NAC helps neutralize harmful free radicals and reduce oxidative stress throughout the body. This antioxidant action not only protects cells and tissues from damage but also supports overall health and vitality.

Furthermore, Gly-NAC exhibits strong anti-inflammatory properties, which can help alleviate inflammation in various tissues and organs. Chronic inflammation is linked to numerous health conditions, including cardiovascular disease, neurodegenerative disorders, and infertility. By reducing inflammation, Gly-NAC may contribute to improved health outcomes and a reduced risk of chronic diseases.

In the context of fertility, Gly-NAC may offer significant benefits for both men and women. Oxidative stress and inflammation are known contributors to infertility, affecting sperm quality, egg health, and overall reproductive function. By addressing these underlying factors, Gly-NAC may help optimize fertility outcomes.

In men, Gly-NAC’s antioxidant properties can protect sperm cells from oxidative damage, preserving their integrity and viability. This can lead to improvements in sperm count, motility, and morphology, all of which are essential for successful conception. Additionally, Gly-NAC’s anti-inflammatory effects may help alleviate conditions such as varicocele, which can impair sperm production and quality.

In women, Gly-NAC may support fertility by promoting a healthy ovarian environment and menstrual cycle regulation. By reducing oxidative stress and inflammation in the ovaries, Gly-NAC can enhance egg quality and hormone balance, increasing the likelihood of successful ovulation and implantation.

Overall, Gly-NAC offers a comprehensive approach to fertility support, addressing key factors such as oxidative stress and inflammation that can impact reproductive health. Incorporating Gly-NAC into a fertility-focused regimen may help improve outcomes for couples struggling with infertility, offering new hope for achieving pregnancy and building a family.

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MYOXCIENCE NAC + Glycine Supreme

  • Pros: Contains NAC and glycine, which may offer synergistic benefits. May support cognitive function, sleep quality, and overall health. Comes in powder form, which is easily absorbed.
  • Cons: More expensive than other NAC supplements. Powdered NAC is an acquired taste! May have a taste that some people find unpleasant. Limited information available about the specific dosage of NAC and glycine
Buy MYOXCIENCE NAC at Amazon SG

Recommended Dosage to Take Melatonin for Fertility

Disclaimer: It’s essential to consult your doctor or a fertility specialist before taking NAC for fertility. They can advise on the appropriate dosage and potential interactions with any medications you’re taking.

While research on NAC and fertility is still ongoing, some studies suggest potential benefits for both men and women:

For Women:

  • Dosage range: Studies have used varying dosages, ranging from 600mg to 2,400mg per day.
  • Conditions studied: PCOS, unexplained infertility.
  • Results: Some studies indicate improved egg quality, ovulation rates, and pregnancy outcomes in certain groups. However, results are not conclusive and further research is needed.

For Men:

  • Dosage range: Similar to women, studies have used varied dosages, ranging from 600mg to 1,800mg per day.
  • Conditions studied: Low sperm count and motility.
  • Results: Some studies suggest improvements in sperm parameters, but again, more research is needed to confirm efficacy across different populations.

Side Effects of Melatonin for Fertility

NAC supplement for fertility is generally considered safe when taken in recommended dosages. However, some potential side effects include:

  • Mild gastrointestinal issues: Nausea, vomiting, diarrhea, stomach upset.
  • Allergic reactions: Rare but possible, including skin rash, itching, wheezing.
  • Exacerbated asthma: In rare cases, it may worsen asthma symptoms.

Additional precautions:

  • NAC may interact with certain medications, including blood thinners. Inform your doctor about all medications you take before starting NAC.
  • Pregnant or breastfeeding women should avoid NAC unless otherwise advised by a healthcare professional.
  • People with certain health conditions like kidney disease or bleeding disorders should consult their doctor before taking NAC.
nac supplement for fertility dosage male female fertility
FAQ About NAC for Fertility

Is NAC good for low AMH?

The short answer is maybe. Some studies suggest NAC may improve ovarian response and egg quality in women with PCOS, which can sometimes lead to lower AMH levels. However, research is limited and inconclusive, and further studies are needed to confirm its effectiveness for specifically low AMH.

What is the role of NAC in fertility?

NAC plays a key role in antioxidant production, boosting glutathione levels which protect cells from damage. This may be beneficial for fertility by:

    • Improving egg and sperm quality.
    • Reducing inflammation in the reproductive system.
    • Supporting a healthy uterine environment for implantation.

More research is needed to fully understand the extent of these benefits and for whom they are most significant.

Does NAC thicken uterine lining?

There is limited evidence suggesting NAC may positively impact uterine lining thickness. Some studies show improvement in women with thin lining, but again, more research is needed for conclusive results.

Does NAC prevent miscarriage?

While some studies suggest a reduced risk of miscarriage with NAC supplementation, others haven’t found similar results. This area requires further investigation to understand if NAC has a clear role in miscarriage prevention.

Conclusion: Is NAC Good for Fertility?

So, is N-Acetyl Cysteine (NAC) worth considering, especially if you’re trying to have a baby? It seems like it might be! Studies suggest it could improve egg and sperm quality, which is super important for getting pregnant. But remember, while NAC has a lot of potential, we still need more research to be sure. So, if you’re thinking about trying it, it’s a good idea to talk to your doctor first. Overall, NAC shows promise in the fertility department, but like with any supplement, it’s best to proceed with caution and get advice from the experts.

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